Answer: In a sense asking this question is sort of like asking how the sun differs from other stars in our solar system—the point being that there are no other stars in our solar system!
The point is that no other “religious leader” even compares to Jesus Christ. Every other religious leader is either alive or dead. Jesus Christ is the only one who was dead (He died in our place, for our sins, according I Corinthians 15:1-8) and is now alive. Indeed, He proclaims in Revelation 1:17-18 that He is alive forever-more! No other religious leader even makes such a claim, a claim that is either true or utterly preposterous.
Another important difference is found in the very nature of Christianity. The essence of Christianity is Christ. Crucified, resurrected, ascended into Heaven, returning someday. Without Him—and without His resurrection—there is no Christianity. Compare that with other major religions. Hinduism, for example, can stand or fall entirely apart from any of the “great Swamis” who founded it. Buddhism is the same story. Even Islam is based upon the sayings and teachings of Mohammed, not upon the claim that he came back to life from the dead.
The Apostle Paul, in 1 Corinthians 15:13-19, says that if Christ was not raised from the dead, then our faith is empty and we are still in our sins! What he is saying is that the truth claims of Christianity are based simply and solely upon the resurrected Jesus Christ! If He did not, in fact, come back from the dead—in time and space—then there is no truth to Christianity whatsoever. Over and over again throughout the New Testament the apostles and evangelists base the truth of the Gospel upon the Resurrection.
One other significant point that we dare not overlook is the exceedingly important fact that Jesus Christ claimed to be the “Son of God” (a Hebraism meaning “characterized by God”) as well as the “Son of Man” (a Hebraism meaning “characterised by Man”). In many varied passages, He makes claims to be equal with the Father (see, for example, John 10:29-33). To Him are ascribed all of the prerogatives and attributes of Deity. Yet He was also a man, born of a virgin (Matthew 1:18-25; Luke 1:26-56). Having lived a sinless life, He was crucified in order to pay for the sins of all men: “He Himself is the satisfaction of God’s wrath for our sins; and not for ours only, but for those of the whole world” (1 John 2:2), and then He was resurrected from the dead three days later. He is fully God and fully Man, the “theanthropos” [from the Greek for God (theos) – Man (anthropos)]; yet He is one person.
The very Person and Work of Christ poses for us a question that we cannot avoid: What will you do with Jesus? We cannot simply dismiss Him. We cannot ignore Him. He is the central figure in all of human history, and if He died for the sins of the whole world, then He died for yours as well. The Apostle Peter tells us in Acts 4:12, “And there is salvation in no one else; for there is no other name under heaven that has been given among men by which we must be saved.” If we believe on the Lord Jesus Christ as our Saviour from sin, we will be saved.